Protein Misfolding Theory of Aging

Protein misfolding is strongly associated with age-related degenerative diseases Aging and stress, stress and aging—these two human conditions, when paired, can profoundly affect the quality of life. When events go awry, molecular processes take place that, over time, can lead … Continue reading

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AGING AS A CONSEQUENCE OF MISREPAIR — A NOVEL THEORY OF AGING

Introduction to A NOVEL THEORY OF AGING – AGING AS A CONSEQUENCE OF MISREPAIR Jicun Wang1, Thomas M. Michelitsch2*, Arne Wunderlin3 and Ravi Mahadeva1 1Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom 2Institut Jean le Rond d’Alembert … Continue reading

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New Theories of Aging – Decline or Defective In Adult (Somatic) Stem Cell Differentiation Functionality

There are 2 broad types of stem cells in our body: 1. embryonic stem cells (ESC) and 2. adult or somatic stem cells (SSC)– the undiffrentiated cells found in adult tissues. Embryonic stem cell is pluripotent meaning it can differentiate differentiate … Continue reading

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The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations

The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations Proc Natl Acad Sci U S A. 2005 December 27; 102(52): 18769–18770 Department of Pathology, University of Washington, Seattle, WA 98195 Mitochondria are … Continue reading

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Stress Speeds Aging

By Rob Stein, Washington Post Staff Writer Scientists have identified the first direct link between stress and aging, a finding that could explain why intense, long-term emotional strain can make people get sick and grow old before their time.

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The most prominent random damage theory of aging — free radical theory of aging

The most prominent random damage theory of aging — free radical theory of aging The most prominent random damage theoryof aging was proposed by Denham Harman in 1955. This theory postulates that free radical reactions, primarily oxygen-free radicals, cause slowly … Continue reading

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